The German side welcome their Spanish counterparts for the first leg this week before the return fixture at the Bernabeu on April 18.
It will also see ex-Real boss Carlo Ancelotti face the La Liga side for the first time since his departure in 2015, with his former assistant - Zinedine Zidane - now the permanent manager.Ancelotti won the Champions League at Real in 2014, before Zidane claimed the trophy last season for the 11-time winners, while Bayern Munich are Europe's joint third most successful team having been crowned champions on five occasions.
But the last time the Bundesliga winners played Real at the Allianz Arena, they suffered their biggest ever European home defeat when they were beaten 4-0 in April 2014, which was also the last time their lost on their own turf in the Champions League.
Team news
Both sides are missing key defenders for the clash
Mats Hummels was ruled out after damaging ankle ligaments on Sunday, so Jerome Boateng and Javi Martinez are expected to form the centre-back partnership.
Real will have defenders Pepe and Raphael Varane ruled out of both legs. The former suffered a double rib fracture in Saturday's 1-1 draw with Atletico Madrid, while the latter is out for a month with a hamstring injury
Right-back Daniel Carvajal trained on his own on Monday and is struggling with a knock.
Bayern received a boost on Monday with Manuel Neuer back in training following a minor foot operation ten days ago, while Thomas Mueller (ankle) and Robert Lewandowski (bruised shoulder) will be avaliable
Bayern will feel like they can get at Zidane's defence, with Robert Lewandowski too much of a handful against Real's back four, who for all their experience are both still rash under pressure.
I'm expecting quite a physical contest here and I'd be looking at backing plenty of yellow cards, and Bayern, with the ability to handle that physical element, capable of establishing a decent advantage.